By Philippe Derreumaux
Alzheimer's ailment is the commonest type of senile dementia, affecting greater than 24 million humans world wide. it truly is characterized pathologically by way of abnormally excessive degrees of neurofibrillary tangles as a result of the buildup of tau protein in lifeless and demise neurons, and by way of increased numbers of senile plaques within the cortex and hippocampus of the mind. the key section of senile plaques is a small protein of 39–43 amino acids referred to as amyloid-β (Aβ). so far, no remedy has been proven to sluggish the development of sporadic and familial Alzheimer's disease.
A huge physique of proof issues, notwithstanding, to the early Aβ-formed oligomers because the fundamental poisonous species in Alzheimer's ailment. a strong procedure for constructing pharmaceutical remedies opposed to Alzheimer's is to explain the pathways of oligomer formation and ensure the buildings of the poisonous aggregates.
This e-book offers a wide ranging view throughout contemporary in vitro and in vivo reports besides state of the art computing device simulations, designed to extend the readers' knowing of Aβ oligomerisation and fibril formation. even as, the booklet delves into the pathogenesis of familial and sporadic Alzheimer's sickness on the atomic point of detail.
Written through prime authors of their respective fields, this publication can be invaluable to all scientists engaged on Alzheimer's disease.
Readership: normal public, PhD scholars, postdocs, in addition to all scientists operating within the following fields: Alzheimer's ailment, amyloids, neuroscience, oligomers, protofibrils, fibrils, toxicity, constructions, dynamics, kinetics, thermodynamics, all-atom and coarse grained simulations, biophysics, reminiscence, studying, transgenic mouse types, steel ions, membrane, nanoparticles, computational chemistry, drug layout and bioinformatics.
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Extra resources for Alzheimer's Disease: Insights into Low Molecular Weight and Cytotoxic Aggregates from In Vitro and Computer Experiments:Molecular Basis of Amyloid-Beta ... (Molecular Medicine and Medicinal Chemistry)
Alzheimer's Disease: Insights into Low Molecular Weight and Cytotoxic Aggregates from In Vitro and Computer Experiments:Molecular Basis of Amyloid-Beta ... (Molecular Medicine and Medicinal Chemistry) by Philippe Derreumaux